Serotonergic loss underlying apathy in Parkinson’s disease
نویسندگان
چکیده
منابع مشابه
Apathy in Alzheimer's disease
Apathy is the most common neuropsychiatric symptom in patients with Alzheimer’s disease (AD). The presence of apathy has been related to greater caregiver distress, decreased quality of life, and increased morbidity. Here we review the most recent studies on this neuropsychiatric syndrome, focusing on prevalence, impact on quality of life, behavioural and neuroimaging studies, and treatment opt...
متن کاملApathy in Alzheimer's disease
In the last few years, a growing number of studies have been devoted to affective disturbances in Alzheimer disease, AD. These studies showed that apathy is a symptom clearly distinct from depression, and that confusion between apathy and depression appears to be one major cause of variability in the assessment of the frequency of depression in AD. We present the results of four studies from ou...
متن کامل[Apathy in Parkinson's disease].
INTRODUCTION Apathy is a behavioural syndrome due to dysfunction of the process that gives rise to actions induced by external or personal stimuli. Apathy is very common in Parkinson's disease, with a prevalence that ranges between 16-48%. Three subtypes of apathy are currently accepted, which are anatomically and functionally different: cognitive, emotional and due to a deficit in auto-activat...
متن کاملImpulsivity and apathy in Parkinson's disease.
Impulse control disorders (ICDs) and apathy are recognized as two important neuropsychiatric syndromes associated with Parkinson's disease (PD), but as yet we understand very little about the cognitive mechanisms underlying them. Here, we review emerging findings, from both human and animal studies, that suggest that impulsivity and apathy are opposite extremes of a dopamine-dependent spectrum ...
متن کاملapathy, and depression in Parkinson’s disease
Objectives: Fatigue and apathy are two of the most common and most disabling non-motor symptoms of Parkinson’s disease (PD). They have a high coincidence and can often be confused; moreover, their relationship is not fully understood. The aim of our study was to describe the coincidence of apathy with different fatigue domains in the presence/ absence of depression and to separately describe th...
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ژورنال
عنوان ژورنال: Brain
سال: 2016
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/aww190